<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Whiteley, Jack T</style></author><author><style face="normal" font="default" size="100%">Fernandes, Sarah</style></author><author><style face="normal" font="default" size="100%">Sharma, Amandeep</style></author><author><style face="normal" font="default" size="100%">Mendes, Ana Paula D</style></author><author><style face="normal" font="default" size="100%">Racha, Vipula</style></author><author><style face="normal" font="default" size="100%">Benassi, Simone K</style></author><author><style face="normal" font="default" size="100%">Marchetto, Maria C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Reaching into the toolbox: Stem cell models to study neuropsychiatric disorders.</style></title><secondary-title><style face="normal" font="default" size="100%">Stem Cell Reports</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Stem Cell Reports</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cell Culture Techniques, Three Dimensional</style></keyword><keyword><style  face="normal" font="default" size="100%">CRISPR-Cas Systems</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Editing</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Induced Pluripotent Stem Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Mental Disorders</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Biological</style></keyword><keyword><style  face="normal" font="default" size="100%">Organoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022 Feb 08</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">187-210</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Recent advances in genetics, molecular biology, and stem cell biology have accelerated our understanding of neuropsychiatric disorders, like autism spectrum disorder (ASD), major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). This progress highlights the incredible complexity of both the human brain and mental illnesses from the biochemical to the cellular level. Contributing to the complexity of neuropsychiatric disorders are their polygenic nature, cellular and brain region interconnectivity, and dysregulation of human-specific neurodevelopmental processes. Here, we discuss available tools, including CRISPR-Cas9, and the applications of these tools to develop cell-based two-dimensional (2D) models and 3D brain organoid models that better represent and unravel the intricacies of neuropsychiatric disorder pathophysiology.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/35063127?dopt=Abstract&lt;/p&gt;
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