<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vadodaria, Krishna C</style></author><author><style face="normal" font="default" size="100%">Mendes, Ana P D</style></author><author><style face="normal" font="default" size="100%">Mei, Arianna</style></author><author><style face="normal" font="default" size="100%">Racha, Vipula</style></author><author><style face="normal" font="default" size="100%">Erikson, Galina</style></author><author><style face="normal" font="default" size="100%">Shokhirev, Maxim N</style></author><author><style face="normal" font="default" size="100%">Oefner, Ruth</style></author><author><style face="normal" font="default" size="100%">Heard, Kelly J</style></author><author><style face="normal" font="default" size="100%">McCarthy, Michael J</style></author><author><style face="normal" font="default" size="100%">Eyler, Lisa</style></author><author><style face="normal" font="default" size="100%">Kelsoe, John R</style></author><author><style face="normal" font="default" size="100%">Santos, Renata</style></author><author><style face="normal" font="default" size="100%">Marchetto, Maria C</style></author><author><style face="normal" font="default" size="100%">Gage, Fred H</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes.</style></title><secondary-title><style face="normal" font="default" size="100%">Stem Cell Reports</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Stem Cell Reports</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Astrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Bipolar Disorder</style></keyword><keyword><style  face="normal" font="default" size="100%">Coculture Techniques</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Induced Pluripotent Stem Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-1beta</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroglia</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurons</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021 Apr 13</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">825-835</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Bipolar disorder (BD) is characterized by cyclical mood shifts. Studies indicate that BD patients have a peripheral pro-inflammatory state and alterations in glial populations in the brain. We utilized an in&amp;nbsp;vitro model to study inflammation-related phenotypes of astrocytes derived from induced pluripotent stem cells (iPSCs) generated from BD patients and healthy controls. BD astrocytes showed changes in transcriptome and induced a reduction in neuronal activity when co-cultured with neurons. IL-1β-stimulated BD astrocytes displayed a unique inflammatory gene expression signature and increased secretion of IL-6. Conditioned medium from stimulated BD astrocytes reduced neuronal activity, and this effect was partially blocked by IL-6 inactivating antibody. Our results suggest that BD astrocytes are functionally less supportive of neuronal excitability and this effect is partially mediated by IL-6. We confirmed higher IL-6 in blood in a distinct cohort of BD patients, highlighting the potential role of astrocyte-mediated inflammatory signaling in BD neuropathology.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/33667413?dopt=Abstract&lt;/p&gt;
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