<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Corcoran, Martin</style></author><author><style face="normal" font="default" size="100%">Chernyshev, Mark</style></author><author><style face="normal" font="default" size="100%">Mandolesi, Marco</style></author><author><style face="normal" font="default" size="100%">Narang, Sanjana</style></author><author><style face="normal" font="default" size="100%">Kaduk, Mateusz</style></author><author><style face="normal" font="default" size="100%">Ye, Kewei</style></author><author><style face="normal" font="default" size="100%">Sundling, Christopher</style></author><author><style face="normal" font="default" size="100%">Färnert, Anna</style></author><author><style face="normal" font="default" size="100%">Kreslavsky, Taras</style></author><author><style face="normal" font="default" size="100%">Bernhardsson, Carolina</style></author><author><style face="normal" font="default" size="100%">Larena, Maximilian</style></author><author><style face="normal" font="default" size="100%">Jakobsson, Mattias</style></author><author><style face="normal" font="default" size="100%">Karlsson Hedestam, Gunilla B</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Archaic humans have contributed to large-scale variation in modern human T cell receptor genes.</style></title><secondary-title><style face="normal" font="default" size="100%">Immunity</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Immunity</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Feb 08</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.sciencedirect.com/science/article/pii/S1074761323000389?via%3Dihub</style></url></web-urls></urls><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Human T&amp;nbsp;cell receptors (TCRs) are critical for mediating immune responses to pathogens and tumors and regulating self-antigen recognition. Yet, variations in the genes encoding TCRs remain insufficiently defined. Detailed analysis of expressed TCR alpha, beta, gamma, and delta genes in 45 donors from four human populations-African, East Asian, South Asian, and European-revealed 175 additional TCR variable and junctional alleles. Most of these contained coding changes and were present at widely differing frequencies in the populations, a finding confirmed using DNA samples from the 1000 Genomes Project. Importantly, we identified three Neanderthal-derived, introgressed TCR regions including a highly divergent TRGV4 variant, which mediated altered butyrophilin-like molecule 3 (BTNL3) ligand reactivity and was frequent in all modern Eurasian population groups. Our results demonstrate remarkable variation in TCR genes in both individuals and populations, providing a strong incentive for including allelic variation in studies of TCR function in human biology.&lt;/p&gt;
</style></abstract><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/36796364?dopt=Abstract&lt;/p&gt;
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