<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Velmeshev, Dmitry</style></author><author><style face="normal" font="default" size="100%">Perez, Yonatan</style></author><author><style face="normal" font="default" size="100%">Yan, Zihan</style></author><author><style face="normal" font="default" size="100%">Valencia, Jonathan E</style></author><author><style face="normal" font="default" size="100%">Castaneda-Castellanos, David R</style></author><author><style face="normal" font="default" size="100%">Wang, Li</style></author><author><style face="normal" font="default" size="100%">Schirmer, Lucas</style></author><author><style face="normal" font="default" size="100%">Mayer, Simone</style></author><author><style face="normal" font="default" size="100%">Wick, Brittney</style></author><author><style face="normal" font="default" size="100%">Wang, Shaohui</style></author><author><style face="normal" font="default" size="100%">Nowakowski, Tomasz Jan</style></author><author><style face="normal" font="default" size="100%">Paredes, Mercedes</style></author><author><style face="normal" font="default" size="100%">Huang, Eric J</style></author><author><style face="normal" font="default" size="100%">Kriegstein, Arnold R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Single-cell analysis of prenatal and postnatal human cortical development.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Oct 13</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.science.org/doi/10.1126/science.adf0834</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">382</style></volume><pages><style face="normal" font="default" size="100%">eadf0834</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We analyzed &amp;gt;700,000 single-nucleus RNA sequencing profiles from 106 donors during prenatal and postnatal developmental stages and identified lineage-specific programs that underlie the development of specific subtypes of excitatory cortical neurons, interneurons, glial cell types, and brain vasculature. By leveraging single-nucleus chromatin accessibility data, we delineated enhancer gene regulatory networks and transcription factors that control commitment of specific cortical lineages. By intersecting our results with genetic risk factors for human brain diseases, we identified the cortical cell types and lineages most vulnerable to genetic insults of different brain disorders, especially autism. We find that lineage-specific gene expression programs up-regulated in female cells are especially enriched for the genetic risk factors of autism. Our study captures the molecular progression of cortical lineages across human development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6667</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/37824647?dopt=Abstract&lt;/p&gt;
</style></custom1></record></records></xml>