<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rogers Flattery, Christina N</style></author><author><style face="normal" font="default" size="100%">Rosen, Rebecca F</style></author><author><style face="normal" font="default" size="100%">Farberg, Aaron S</style></author><author><style face="normal" font="default" size="100%">Dooyema, Jeromy M</style></author><author><style face="normal" font="default" size="100%">Hof, Patrick R</style></author><author><style face="normal" font="default" size="100%">Sherwood, Chet C</style></author><author><style face="normal" font="default" size="100%">Walker, Lary C</style></author><author><style face="normal" font="default" size="100%">Preuss, Todd M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans.</style></title><secondary-title><style face="normal" font="default" size="100%">Brain Struct Funct</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Brain Struct Funct</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amyloid beta-Peptides</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Hippocampus</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaca mulatta</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurons</style></keyword><keyword><style  face="normal" font="default" size="100%">Pan troglodytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Phosphorylation</style></keyword><keyword><style  face="normal" font="default" size="100%">tau Proteins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 Nov</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">225</style></volume><pages><style face="normal" font="default" size="100%">2521-2531</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, and it contributes to abilities thought to be uniquely human, yet little is known about how the human hippocampal formation compares to that of our closest living relatives, the chimpanzees. To gain insight into the comparative organization of the hippocampal formation in catarrhine primates, we quantified neurons stereologically in its major subdivisions-the granular layer of the dentate gyrus, CA4, CA2-3, CA1, and the subiculum-in archival brain tissue from six chimpanzees ranging from 29 to 43&amp;nbsp;years of age. We also sought evidence of&amp;nbsp;Aβ&amp;nbsp;deposition and hyperphosphorylated tau in the hippocampus and adjacent neocortex. A 42-year-old animal had moderate cerebral&amp;nbsp;Aβ-amyloid angiopathy and tauopathy, but&amp;nbsp;Aβ&amp;nbsp;was absent and tauopathy was minimal in the others. Quantitatively, granule cells of the dentate gyrus were most numerous, followed by CA1, subiculum, CA4, and CA2-3.&amp;nbsp;In the context of prior investigations of rhesus monkeys and humans, our findings indicate that, in the hippocampal formation as a whole, the proportions of neurons in CA1 and the subiculum progressively increase, and the proportion of dentate granule cells decreases, from rhesus monkeys to chimpanzees to humans. Because CA1 and the subiculum engender key hippocampal projection pathways to the neocortex, and because the neocortex varies in volume and anatomical organization among these species, these findings suggest that differences in the proportions of neurons in hippocampal subregions of catarrhine primates may be linked to neocortical evolution.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/32909100?dopt=Abstract&lt;/p&gt;
</style></custom1></record></records></xml>