<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Allouche, Jennifer</style></author><author><style face="normal" font="default" size="100%">Rachmin, Inbal</style></author><author><style face="normal" font="default" size="100%">Adhikari, Kaustubh</style></author><author><style face="normal" font="default" size="100%">Pardo, Luba M</style></author><author><style face="normal" font="default" size="100%">Lee, Ju Hee</style></author><author><style face="normal" font="default" size="100%">McConnell, Alicia M</style></author><author><style face="normal" font="default" size="100%">Kato, Shinichiro</style></author><author><style face="normal" font="default" size="100%">Fan, Shaohua</style></author><author><style face="normal" font="default" size="100%">Kawakami, Akinori</style></author><author><style face="normal" font="default" size="100%">Suita, Yusuke</style></author><author><style face="normal" font="default" size="100%">Wakamatsu, Kazumasa</style></author><author><style face="normal" font="default" size="100%">Igras, Vivien</style></author><author><style face="normal" font="default" size="100%">Zhang, Jianming</style></author><author><style face="normal" font="default" size="100%">Navarro, Paula P</style></author><author><style face="normal" font="default" size="100%">Lugo, Camila Makhlouta</style></author><author><style face="normal" font="default" size="100%">Noonan, Haley R</style></author><author><style face="normal" font="default" size="100%">Christie, Kathleen A</style></author><author><style face="normal" font="default" size="100%">Itin, Kaspar</style></author><author><style face="normal" font="default" size="100%">Mujahid, Nisma</style></author><author><style face="normal" font="default" size="100%">Lo, Jennifer A</style></author><author><style face="normal" font="default" size="100%">Won, Chong Hyun</style></author><author><style face="normal" font="default" size="100%">Evans, Conor L</style></author><author><style face="normal" font="default" size="100%">Weng, Qing Yu</style></author><author><style face="normal" font="default" size="100%">Wang, Hequn</style></author><author><style face="normal" font="default" size="100%">Osseiran, Sam</style></author><author><style face="normal" font="default" size="100%">Lovas, Alyssa</style></author><author><style face="normal" font="default" size="100%">Németh, István</style></author><author><style face="normal" font="default" size="100%">Cozzio, Antonio</style></author><author><style face="normal" font="default" size="100%">Navarini, Alexander A</style></author><author><style face="normal" font="default" size="100%">Hsiao, Jennifer J</style></author><author><style face="normal" font="default" size="100%">Nguyen, Nhu</style></author><author><style face="normal" font="default" size="100%">Kemény, Lajos V</style></author><author><style face="normal" font="default" size="100%">Iliopoulos, Othon</style></author><author><style face="normal" font="default" size="100%">Berking, Carola</style></author><author><style face="normal" font="default" size="100%">Ruzicka, Thomas</style></author><author><style face="normal" font="default" size="100%">González-José, Rolando</style></author><author><style face="normal" font="default" size="100%">Bortolini, Maria-Cátira</style></author><author><style face="normal" font="default" size="100%">Canizales-Quinteros, Samuel</style></author><author><style face="normal" font="default" size="100%">Acuna-Alonso, Victor</style></author><author><style face="normal" font="default" size="100%">Gallo, Carla</style></author><author><style face="normal" font="default" size="100%">Poletti, Giovanni</style></author><author><style face="normal" font="default" size="100%">Bedoya, Gabriel</style></author><author><style face="normal" font="default" size="100%">Rothhammer, Francisco</style></author><author><style face="normal" font="default" size="100%">Ito, Shosuke</style></author><author><style face="normal" font="default" size="100%">Schiaffino, Maria Vittoria</style></author><author><style face="normal" font="default" size="100%">Chao, Luke H</style></author><author><style face="normal" font="default" size="100%">Kleinstiver, Benjamin P</style></author><author><style face="normal" font="default" size="100%">Tishkoff, Sarah</style></author><author><style face="normal" font="default" size="100%">Zon, Leonard I</style></author><author><style face="normal" font="default" size="100%">Nijsten, Tamar</style></author><author><style face="normal" font="default" size="100%">Ruiz-Linares, Andres</style></author><author><style face="normal" font="default" size="100%">Fisher, David E</style></author><author><style face="normal" font="default" size="100%">Roider, Elisabeth</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.</style></title><secondary-title><style face="normal" font="default" size="100%">Cell</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Cell</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cohort Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyclic AMP</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Damage</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme Inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">melanocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanosomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Inbred C57BL</style></keyword><keyword><style  face="normal" font="default" size="100%">Microphthalmia-Associated Transcription Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitochondria</style></keyword><keyword><style  face="normal" font="default" size="100%">Monophenol Monooxygenase</style></keyword><keyword><style  face="normal" font="default" size="100%">NADP Transhydrogenases</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidation-Reduction</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteasome Endopeptidase Complex</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteolysis</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA, Messenger</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin Pigmentation</style></keyword><keyword><style  face="normal" font="default" size="100%">Ubiquitin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultraviolet Rays</style></keyword><keyword><style  face="normal" font="default" size="100%">Zebrafish</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021 Aug 05</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">184</style></volume><pages><style face="normal" font="default" size="100%">4268-4283.e20</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mitochondrial redox-regulating enzyme nicotinamide nucleotide transhydrogenase (NNT) resulted in cellular redox changes that affect tyrosinase degradation. These changes regulate melanosome maturation and, consequently, eumelanin levels and pigmentation. Topical application of small-molecule inhibitors yielded skin darkening in human skin, and mice with decreased NNT function displayed increased pigmentation. Additionally, genetic modification of NNT in zebrafish alters melanocytic pigmentation. Analysis of four diverse human cohorts revealed significant associations of skin color, tanning, and sun protection use with various single-nucleotide polymorphisms within NNT. NNT levels were independent of UVB irradiation and redox modulation. Individuals with postinflammatory hyperpigmentation or lentigines displayed decreased skin NNT levels, suggesting an NNT-driven, redox-dependent pigmentation mechanism that can be targeted with NNT-modifying topical drugs for medical and cosmetic purposes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">16</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/34233163?dopt=Abstract&lt;/p&gt;
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