<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fan, Shaohua</style></author><author><style face="normal" font="default" size="100%">Spence, Jeffrey P</style></author><author><style face="normal" font="default" size="100%">Feng, Yuanqing</style></author><author><style face="normal" font="default" size="100%">Hansen, Matthew E B</style></author><author><style face="normal" font="default" size="100%">Terhorst, Jonathan</style></author><author><style face="normal" font="default" size="100%">Beltrame, Marcia H</style></author><author><style face="normal" font="default" size="100%">Ranciaro, Alessia</style></author><author><style face="normal" font="default" size="100%">Hirbo, Jibril</style></author><author><style face="normal" font="default" size="100%">Beggs, William</style></author><author><style face="normal" font="default" size="100%">Thomas, Neil</style></author><author><style face="normal" font="default" size="100%">Nyambo, Thomas</style></author><author><style face="normal" font="default" size="100%">Mpoloka, Sununguko Wata</style></author><author><style face="normal" font="default" size="100%">Mokone, Gaonyadiwe George</style></author><author><style face="normal" font="default" size="100%">Njamnshi, Alfred</style></author><author><style face="normal" font="default" size="100%">Folkunang, Charles</style></author><author><style face="normal" font="default" size="100%">Meskel, Dawit Wolde</style></author><author><style face="normal" font="default" size="100%">Belay, Gurja</style></author><author><style face="normal" font="default" size="100%">Song, Yun S</style></author><author><style face="normal" font="default" size="100%">Tishkoff, Sarah A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation.</style></title><secondary-title><style face="normal" font="default" size="100%">Cell</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Cell</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3-Phosphoinositide-Dependent Protein Kinases</style></keyword><keyword><style  face="normal" font="default" size="100%">Acclimatization</style></keyword><keyword><style  face="normal" font="default" size="100%">Africa</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Population Density</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin Pigmentation</style></keyword><keyword><style  face="normal" font="default" size="100%">Whole Genome Sequencing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Mar 02</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">186</style></volume><pages><style face="normal" font="default" size="100%">923-939.e14</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We conduct high coverage (&amp;gt;30×) whole-genome sequencing of 180 individuals from 12 indigenous African populations. We identify millions of unreported variants, many predicted to be functionally important. We observe that the ancestors of southern African San and central African rainforest hunter-gatherers (RHG) diverged from other populations &amp;gt;200 kya and maintained a large effective population size. We observe evidence for ancient population structure in Africa and for multiple introgression events from &quot;ghost&quot; populations with highly diverged genetic lineages. Although currently geographically isolated, we observe evidence for gene flow between eastern and southern Khoesan-speaking hunter-gatherer populations lasting until ∼12&amp;nbsp;kya. We identify signatures of local adaptation for traits related to skin color, immune response, height, and metabolic processes. We identify a positively selected variant in the lightly pigmented San that influences pigmentation in&amp;nbsp;vitro by regulating the enhancer activity and gene expression of PDPK1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/36868214?dopt=Abstract&lt;/p&gt;
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