<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Janivara, Rohini</style></author><author><style face="normal" font="default" size="100%">Chen, Wenlong C</style></author><author><style face="normal" font="default" size="100%">Hazra, Ujani</style></author><author><style face="normal" font="default" size="100%">Baichoo, Shakuntala</style></author><author><style face="normal" font="default" size="100%">Agalliu, Ilir</style></author><author><style face="normal" font="default" size="100%">Kachambwa, Paidamoyo</style></author><author><style face="normal" font="default" size="100%">Simonti, Corrine N</style></author><author><style face="normal" font="default" size="100%">Brown, Lyda M</style></author><author><style face="normal" font="default" size="100%">Tambe, Saanika P</style></author><author><style face="normal" font="default" size="100%">Kim, Michelle S</style></author><author><style face="normal" font="default" size="100%">Harlemon, Maxine</style></author><author><style face="normal" font="default" size="100%">Jalloh, Mohamed</style></author><author><style face="normal" font="default" size="100%">Muzondiwa, Dillon</style></author><author><style face="normal" font="default" size="100%">Naidoo, Daphne</style></author><author><style face="normal" font="default" size="100%">Ajayi, Olabode O</style></author><author><style face="normal" font="default" size="100%">Snyper, Nana Yaa</style></author><author><style face="normal" font="default" size="100%">Niang, Lamine</style></author><author><style face="normal" font="default" size="100%">Diop, Halimatou</style></author><author><style face="normal" font="default" size="100%">Ndoye, Medina</style></author><author><style face="normal" font="default" size="100%">Mensah, James E</style></author><author><style face="normal" font="default" size="100%">Abrahams, Afua O D</style></author><author><style face="normal" font="default" size="100%">Biritwum, Richard</style></author><author><style face="normal" font="default" size="100%">Adjei, Andrew A</style></author><author><style face="normal" font="default" size="100%">Adebiyi, Akindele O</style></author><author><style face="normal" font="default" size="100%">Shittu, Olayiwola</style></author><author><style face="normal" font="default" size="100%">Ogunbiyi, Olufemi</style></author><author><style face="normal" font="default" size="100%">Adebayo, Sikiru</style></author><author><style face="normal" font="default" size="100%">Nwegbu, Maxwell M</style></author><author><style face="normal" font="default" size="100%">Ajibola, Hafees O</style></author><author><style face="normal" font="default" size="100%">Oluwole, Olabode P</style></author><author><style face="normal" font="default" size="100%">Jamda, Mustapha A</style></author><author><style face="normal" font="default" size="100%">Pentz, Audrey</style></author><author><style face="normal" font="default" size="100%">Haiman, Christopher A</style></author><author><style face="normal" font="default" size="100%">Spies, Petrus V</style></author><author><style face="normal" font="default" size="100%">van der Merwe, André</style></author><author><style face="normal" font="default" size="100%">Cook, Michael B</style></author><author><style face="normal" font="default" size="100%">Chanock, Stephen J</style></author><author><style face="normal" font="default" size="100%">Berndt, Sonja I</style></author><author><style face="normal" font="default" size="100%">Watya, Stephen</style></author><author><style face="normal" font="default" size="100%">Lubwama, Alexander</style></author><author><style face="normal" font="default" size="100%">Muchengeti, Mazvita</style></author><author><style face="normal" font="default" size="100%">Doherty, Sean</style></author><author><style face="normal" font="default" size="100%">Smyth, Natalie</style></author><author><style face="normal" font="default" size="100%">Lounsbury, David</style></author><author><style face="normal" font="default" size="100%">Fortier, Brian</style></author><author><style face="normal" font="default" size="100%">Rohan, Thomas E</style></author><author><style face="normal" font="default" size="100%">Jacobson, Judith S</style></author><author><style face="normal" font="default" size="100%">Neugut, Alfred I</style></author><author><style face="normal" font="default" size="100%">Hsing, Ann W</style></author><author><style face="normal" font="default" size="100%">Gusev, Alexander</style></author><author><style face="normal" font="default" size="100%">Aisuodionoe-Shadrach, Oseremen I</style></author><author><style face="normal" font="default" size="100%">Joffe, Maureen</style></author><author><style face="normal" font="default" size="100%">Adusei, Ben</style></author><author><style face="normal" font="default" size="100%">Gueye, Serigne M</style></author><author><style face="normal" font="default" size="100%">Fernandez, Pedro W</style></author><author><style face="normal" font="default" size="100%">McBride, Jo</style></author><author><style face="normal" font="default" size="100%">Andrews, Caroline</style></author><author><style face="normal" font="default" size="100%">Petersen, Lindsay N</style></author><author><style face="normal" font="default" size="100%">Lachance, Joseph</style></author><author><style face="normal" font="default" size="100%">Rebbeck, Timothy R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat Genet</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Africa South of the Sahara</style></keyword><keyword><style  face="normal" font="default" size="100%">Alleles</style></keyword><keyword><style  face="normal" font="default" size="100%">Black People</style></keyword><keyword><style  face="normal" font="default" size="100%">Case-Control Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Frequency</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetics, Population</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome-Wide Association Study</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplotypes</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Prostatic Neoplasms</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024 Oct</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.nature.com/articles/s41588-024-01931-3#citeas</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">56</style></volume><pages><style face="normal" font="default" size="100%">2093-2103</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Men of African descent have the highest prostate cancer incidence and mortality rates, yet the genetic basis of prostate cancer in African men has been understudied. We used genomic data from 3,963 cases and 3,509 controls from Ghana, Nigeria, Senegal, South Africa and Uganda to infer ancestry-specific genetic architectures and fine-map disease associations. Fifteen independent associations at 8q24.21, 6q22.1 and 11q13.3 reached genome-wide significance, including four new associations. Intriguingly, multiple lead associations are private alleles, a pattern arising from recent mutations and the out-of-Africa bottleneck. These African-specific alleles contribute to haplotypes with odds ratios above 2.4. We found that the genetic architecture of prostate cancer differs across Africa, with effect size differences contributing more to this heterogeneity than allele frequency differences. Population genetic analyses reveal that African prostate cancer associations are largely governed by neutral evolution. Collectively, our findings emphasize the utility of conducting genetic studies that use diverse populations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue><custom1><style face="normal" font="default" size="100%">&lt;p&gt;https://www.ncbi.nlm.nih.gov/pubmed/39358599?dopt=Abstract&lt;/p&gt;
</style></custom1></record></records></xml>