CAAStools: a toolbox to identify and test Convergent Amino Acid Substitutions.
Bibliographic Collection:
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Barteri, Fabio; Valenzuela, Alejandro; Farré, Xavier; de Juan, David; Muntané, Gerard; Esteve-Altava, Borja; Navarro, Arcadi
Year of Publication: 2023
Journal: Bioinformatics
Volume: 39
Issue: 10
Date Published: 2023 Oct 03
Publication Language: eng
ISSN: 1367-4811
Keywords: Amino Acid Substitution, Computational Biology, Documentation, Phylogeny, Software
Abstract:
MOTIVATION: Coincidence of Convergent Amino Acid Substitutions (CAAS) with phenotypic convergences allow pinpointing genes and even individual mutations that are likely to be associated with trait variation within their phylogenetic context. Such findings can provide useful insights into the genetic architecture of complex phenotypes.
RESULTS: Here we introduce CAAStools, a set of bioinformatics tools to identify and validate CAAS in orthologous protein alignments for predefined groups of species representing the phenotypic values targeted by the user.
AVAILABILITY AND IMPLEMENTATION: CAAStools source code is available at http://github.com/linudz/caastools, along with documentation and examples.
DOI: 10.1093/bioinformatics/btad623
Alternate Journal: Bioinformatics
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