A fine-scale map of recombination rates and hotspots across the human genome.

Bibliographic Collection:

MOCA Reference, APE

Publication Type: Journal Article

Authors: Myers, Simon; Bottolo, Leonardo; Freeman, Colin; McVean, Gil; Donnelly, Peter

Year of Publication: 2005

Journal: Science

Volume: 310

Issue: 5746

Pagination: 321-4

Date Published: 10/2005

Publication Language: eng

ISSN: 1095-9203

Keywords: Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Evolution, Molecular, Female, Genome, Human, Humans, Male, Models, Genetic, Polymorphism, Single Nucleotide, Recombination, Genetic

Abstract:

Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.

DOI: 10.1126/science.1117196

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/16224025?dopt=Abstract

Alternate Journal: Science

Export: