CDK5RAP2 (CDK5 regulatory subunit-associated protein 2)
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CDK5 regulatory subunit associated protein 2 (CDK5RAP2) is a centrosomal protein involved in neuronal differentiation. CDK5RAP2 is also known as MCPH3, as it is one of seven genes causative of primary microcephaly. This gene has undergone accelerated evolution and positive selection throughout the anthropoid lineages and specifically in the human lineage. These changes have been associated with neonatal brain mass and have led to the hypothesis that CDK5RAP2 may be involved in human brain size evolution.
Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates., , Mol Biol Evol, 2011 Jan, Volume 28, Issue 1, p.625-38, (2011)
Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ, , Gene, Volume 375, p.75 - 79, (2006)