FRMPD2 (FERM and PDZ domain containing 2)
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Human Uniqueness Compared to "Great Apes":
FERM and PDZ domain containing 2 (FRMPD2) is a peripheral membrane protein and is involved in polarizing and formation of tight cell-cell junctions in epithelial cells. FRMPD2 has approximately 2 more copies in the human genome than in other primates. The significance of these other copies is not understood.
Diversity of human copy number variation and multicopy genes., , Science, 10/2010, Volume 330, Issue 6004, p.641-6, (2010)
PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells., , J Cell Sci, 09/2009, Volume 122, Issue Pt 18, p.3374-84, (2009)