GADD45G (Growth arrest and DNA-damage-inducible protein 45 gamma)
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Growth Arrest and DNA-Damage-Inducible, Gamma (GADD45g) is a tumor suppressor important in DNA demethylation and has been shown to be important to cognition. GADD45G is abnormally expressed in individuals with neurodevelopmental, neurological, and psychiatric disorders. A human specific 3 kb deletion of a forebrain specific enhancer for GADD45G leading to the hypothesis that the loss may be involved in expansion of the human forebrain.
Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory., , Learn Mem, 2012, Volume 19, Issue 8, p.319-24, (2012)
Human-specific loss of regulatory DNA and the evolution of human-specific traits., , Nature, 2011 Mar 10, Volume 471, Issue 7337, p.216-9, (2011)