Segmental duplications and the evolution of the primate genome.

Bibliographic Collection:

MOCA Reference, APE

Publication Type: Journal Article

Authors: Samonte, Rhea Vallente; Eichler, Evan E

Year of Publication: 2002

Journal: Nat Rev Genet

Volume: 3

Issue: 1

Pagination: 65-72

Date Published: 2002 Jan

Publication Language: eng

ISSN: 1471-0056

Keywords: Amino Acid Sequence, Animals, Biological Evolution, Chromosomes, Human, Evolution, Molecular, Exons, Gene Duplication, Genome, Human, Haplorhini, Humans, Molecular Sequence Data, Polyploidy, Sequence Homology, Amino Acid

Abstract:

Initial human genome sequence analysis has revealed large segments of nearly identical sequence in particular chromosomal regions. The recent origin of these segments and their abundance (approximately 5%) has challenged investigators to elucidate their underlying mechanism and role in primate genome evolution. Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes.

DOI: 10.1038/nrg705

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/11823792?dopt=Abstract

Alternate Journal: Nat. Rev. Genet.

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