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C22orf45 (Chromosome 22 open reading frame 45)

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Human Uniqueness Compared to "Great Apes": 
Absolute Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

C22orf45 evolved from ancestrally noncoding DNA, which has been verified by the presence of disabling sequences in chimp, gorilla, gibbon, macaque, and mouse. The function and evolutionary significance of C22orf45 is unknown.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
C22orf45 (C22orf45: chromosome 22 open reading frame 45)
Type of Human-Specific Changes:
De Novo Human Gene
Related MOCA Topics
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
6000 Thousand Years
References: 

Knowles DG and McLysaght A.(2009) Recent de novo origin of human protein-coding genes. Genome Res 19(10):1752-9. PMID: 19726446

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