Cholera

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Medical Disease
MOCA Topic Authors: 

Cholera is caused by the bacterium Vibrio cholerae, which secretes a toxin whose B subunit binds the cell surface ganglioside GM1, delivering a toxic A subunit to the interior of the intestinal cell, causing watery diarrhea. The famous bacteriologist Robert Koch found that he could not infect any other animals with the organism, and concluded that "...although these experiments were constantly repeated with material from fresh cholera cases, our mice remained healthy. We then made experiments on monkeys, cats, poultry, dogs and various other animals that we were able to get a hold of, but we never were able to arrive at anything in animals similar to the cholera". The reasons for this are unknown.  There are statements in the literature that chimpanzees are also resistant to cholera. 

Related MOCA Topics
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Possible Appearance: 
6000 Thousand Years
Probable Appearance: 
2000 Thousand Years
Definite Appearance: 
100 Thousand Years