Home » MOCA » Domains » Genetics

CLLU1 (Chronic lymphocytic leukemia up-regulated 1)

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Absolute Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

CLLU1, chronic lymphocytic leukemia up-regulated 1, is a de novo human gene originally identified as being uniquely up-regulated in patients with a particularly aggressive form of chronic lymphocytic leukemia. Increasing CLLU1 protein levels have been associated with poor clinical outcome and are currently being used as a prognostic indicator for the disease. CLLU1 evolved from ancestrally noncoding DNA, which has been verified by the presence of disabling sequences in chimp, gorilla, gibbon, macaque, and mouse. The function and evolutionary significance of CLLU1 is completely unknown.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
CLLU1 (CLLU1: chronic lymphocytic leukemia up-regulated 1)
Type of Human-Specific Changes:
De Novo Human Gene
Related MOCA Topics
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
6000 Thousand Years
References: 

Knowles DG and McLysaght A.(2009) Recent de novo origin of human protein-coding genes. Genome Res 19(10):1752-9. PMID: 19726446

»