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DDX11L (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 like)

Certainty Style Key
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Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

DEAD/H box polypeptide 11-like gene (DDX11L) is a gene that propagated in the subtelomeric regions of the human genome. It is present and expressed from the subtelomeric regions of at least 14 chromosomes. Its precursor gene, DDX11, is a RNA helicase and is hypothesized to function in maintenance of chromosome transmission fidelity and genome stability. The ramifications of the copy number expansion of this gene in the human lineage is as of yet unknown.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
DDX11 (DDX11: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11)
Type of Human-Specific Changes:
Copy Number Changes
Related MOCA Topics
Referenced By:
TitleCertainty
Telomere Expansion, Contraction and Subtelomeric RearrangementTrue
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
6000 Thousand Years
References: 

Armengol G, Knuutila S, Lozano JJ, Madrigal I, Caballín MR. (2010) Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR. Genomics 95(4):203-9. PMID:20153417

 

Costa V, Casamassimi A, Roberto R, Gianfrancesco F, Matarazzo MR, D'Urso M, D'Esposito M, Rocchi M, Ciccodicola A. (2009) DDX11L: a novel transcript family emerging from human subtelomeric regions. BMC Genomics. 2009 May 28;10:250. PMID: 19476624



Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. (2004) Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol 2(7):E207. PMID: 15252450

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