DUSP22 (Dual specificity phosphatase 22)

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 

Dual specificity phosphatase 22 (DUSP22), also known as JNK pathway-associated phosphatase, is involved in the mediation of multiple signaling cascades that are responsible for many different types of signaling, including reaction to stress and inflammation and cell migration. DUSP22 exists at 1-3 more copies in the human genome than in any other primate. The significance of this higher copy number is as of yet unknown.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
DUSP22 (DUSP22: dual specificity phosphatase 22)
Type of Human-Specific Changes:
Copy Number Changes
Related MOCA Topics
Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are currently defined as:

  • the Last Common Ancestor (LCA) of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the Last Common Ancestor (LCA) of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of Homo ergaster was 2000 thousand (2 million) years ago
  • the Last Common Ancestor (LCA) of humans and neanderthals was 400 thousand years ago
  • the common ancestor of modern humans was 100 thousand years ago

Definite Appearance: 
6000 Thousand Years
References: 

Sudmant PH, Kitzman JO, Antonacci F, Alkan C, Malig M, Tsalenko A, Sampas N, Bruhn L, Shendure J; 1000 Genomes Project, Eichler EE. Diversity of human copy number variation and multicopy genes. Science. 2010 Oct 29;330(6004):641-6. PMID:21030649

 

Li JP, Fu YN, Chen YR, Tan TH. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J Biol Chem. 2010 Feb 19;285(8):5472-8. Epub 2009 Dec 14. PMID: 20018849

 

Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. (2004) Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol 2(7):E207. PMID: 15252450