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Kruppel-type Zinc Finger Family

Certainty Style Key
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True   Likely   Speculative
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Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Gene Family Expansion and Loss
MOCA Topic Authors: 
Veronica Searles
James Sikela

Zinc finger proteins are a family of transcription factors that regulate gene expression, and most of these proteins are members of the KZNF family. There are 7 human-specific novel KZNFs and 10 KZNFs that have undergone pseudogenization specifically in the human lineage. 30 additional KZNFs have experienced human-specific sequence changes that are presumed to be of functional significance. Members of the KZNF family are often in regions of segmental duplications, and multiple KZNFs have undergone human-specific duplications and inversions.

Related MOCA Topics
Related Topics:
TitleCertainty
Novel Segmental Duplications/Low Copy RepeatsTrue
ZNF322 (Zinc finger protein 322)True
The Human Difference: 

Pseudogenization
Copy number change
Inversion
Gene deletion
Novel genes

References: 

Nowick K, Fields C, Gernat T et al (2011). Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between species. PLoS ONE 6(6):e21553.

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