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MBL1P (mannose-binding lectin (protein A) 1, pseudogene)

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Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

Mannose-binding lectin 1 (MBL1) is a member of the collectin family and is involved in binding multiple types of microorganisms to activate the lectin-complimentary pathway of innate immunity. Most mammals, including rodents and primates have two MBL genes, 1 and 2, however MBL1 has become a pseudogene in the human lineage. Implications for this loss are not understood.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
MBL1P (MBL1P: mannose-binding lectin (protein A) 1, pseudogene)
Type of Human-Specific Changes:
Pseudogenization
Related MOCA Topics
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Possible Appearance: 
4500 Thousand Years
Definite Appearance: 
6000 Thousand Years
References: 

Kim HL, Igawa T, Kawashima A, Satta Y, Takahata N. (2010) Divergence, demography and gene loss along the human lineage. Philos Trans R Soc Lond B Biol Sci. 365(1552):2451-7.PMID: 20643734

 

Zhang ZD, Frankish A, Hunt T, Harrow J, Gerstein M. (2010) Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. Genome Biol. 11(3):R26. PMID: 20210993

 

Phatsara C, Jennen DG, Ponsuksili S, Murani E, Tesfaye D, Schellander K, Wimmers K. Molecular genetic analysis of porcine mannose-binding lectin genes, MBL1 and MBL2, and their association with complement activity. Int J Immunogenet. 2007 Feb;34(1):55-63. PMID: 17284229


Sastry R, Wang JS, Brown DC, Ezekowitz RA, Tauber AI, Sastry KN. Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes. Mamm Genome. 1995 Feb;6(2):103-10. PMID: 7766991
 

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