Home » MOCA » Domains » Genetics

RAB3IP (RAB3A interacting protein)

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

RAB3A Interacting Protein (RAB3IP) is a homolog of a Ras-like GTPase interactor protein which is involved in actin remodeling and mediation of polarized membrane traffic. An L1 element integrated into an intron of the RAB3A gene, resulting in a human specific transcript. The significance of this human specific transcript is not known.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
RAB3IP (RAB3IP: RAB3A interacting protein (rabin3))
Type of Human-Specific Changes:
Expression Pattern Change
Related MOCA Topics
Related Topics:
TitleCertainty
Novel Long Interspersed Elements (LINEs) and Subfamily ExpansionsTrue
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
6000 Thousand Years
References: 

Kim DS and Hahn Y. (2011) Identification of human-specific transcript variants induced by DNA insertions in the human genome. Bioinformatics 27(1):14-21.PMID: 21037245

 

Hattula K, Furuhjelm J, Arffman A, Peränen J. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Mol Biol Cell. 2002 Sep;13(9):3268-80. PMID: 12221131

»