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RGS6 (Regulator of G-protein signaling 6)

Certainty Style Key
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What is MOCA?
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Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

Regulator of G-protein signaling 6 (RGS6) is a negative regulator of G-protein signaling in multiple pathways important to cardiac and neuronal function and cancer susceptibility. An L1 element inserted into the 5’ upstream promoter of RGS6 resulting in a change in the expression in the human lineage. The significance of this change is not understood.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
RGS6 (RGS6: regulator of G-protein signaling 6)
Type of Human-Specific Changes:
Expression Pattern Change
Related MOCA Topics
Related Topics:
TitleCertainty
Novel Long Interspersed Elements (LINEs) and Subfamily ExpansionsTrue
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
6000 Thousand Years
References: 

Kim DS and Hahn Y. (2011) Identification of human-specific transcript variants induced by DNA insertions in the human genome. Bioinformatics 27(1):14-21.PMID: 21037245

 

Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, Anderson ME, Fisher RA. RGS6, a modulator of parasympathetic activation in heart. Circ Res. 2010 Nov 26;107(11):1345-9. Epub 2010 PMID: 20864673

 


Anderson GR, Posokhova E, Martemyanov KA. The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell Biochem Biophys. 2009;54(1-3):33-46. PMID: 19521673

 


Berman DM, Wang Y, Liu Z, Dong Q, Burke LA, Liotta LA, Fisher R, Wu X. A functional polymorphism in RGS6 modulates the risk of bladder cancer. Cancer Res. 2004 Sep 15;64(18):6820-6. PMID: 15375002
 

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