Siglec Expression in Extra-Embryonic Fetal Tissue

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True Likely Speculative

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Human Uniqueness Compared to "Great Apes":

Likely Difference

MOCA Domain:

Reproductive Biology and Disease

MOCA Topic Authors:

Nissi Varki

Siglecs are sialic acid-recognizing receptors typically found on immune cells. There is one report of Siglec expression in Extra-Embryonic Fetal Tissue, i.e. Siglec-6 expression in the placental trophoblast. This expression is not found in placentae from great apes. Interestingly, Siglec-6 expression is further upregulated in pre-eclampsia, an apparently "human-specific" disease.