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TBC1D3 (TBC domain family, member 3)

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Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

TBC1 domain family member 1 (TBC1D3) is an oncogene that enhances the cellular response to epidermal growth factor. TBC1D3 is a primate specific protein that evolved ~25 million years ago, but has undergone a human lineage specific expansion to 8 copies. The implications of these copies are as of yet unknown.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
TBC1D3 (TBC1D3: TBC1 domain family, member 3)
Type of Human-Specific Changes:
Copy Number Changes
Related MOCA Topics
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
6000 Thousand Years
References: 

Stahl PD and Wainszelbaum MJ. (2009) Human-specific genes may offer a unique window into human cell signaling. Sci Signal. 2(89):pe59. PMID: 19797272

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