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MRC1 (Mannose receptor, C type 1)

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What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

Mannose Receptor, C type 1 (MRC1) is a membrane receptor that mediates the endocytosis of glycoproteins by macrophages. MRC1 binds mannose structures on the surface of viruses, bacteria, and fungi to be neutralized by phagocytosis. Changes in MCR1 have been associated with multiple diseases including the development of leprosy, sarcoidosis, Alzheimer’s disease, and asthma. Human has more copies of MRC1 than any other primate which could have had important implications for the multiple diseases that MRC1 may be involved in.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
MRC1 (MRC1: mannose receptor, C type 1)
Type of Human-Specific Changes:
Copy Number Changes
Related MOCA Topics
Related Topics:
TitleCertainty
Alzheimer's Pathology (Neurofibrillary Tangles)Likely
Bronchial AsthmaLikely
SarcoidosisLikely
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
6000 Thousand Years
References: 

Cardoso CC, Pereira AC, de Sales Marques C, Moraes MO. Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome. Future Microbiol. 2011 May;6(5):533-49. PMID: 21585261


Hattori T, Konno S, Takahashi A, Isada A, Shimizu K, Shimizu K, Taniguchi N, Gao P, Yamaguchi E, Hizawa N, Huang SK, Nishimura M. Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis. BMC Med Genet. 2010 Oct 28;11:151. PMID: 21029423
 

Itan Y, Bryson K, Thomas MG. (2010) Detecting gene duplications in the human lineage. Ann Hum Genet. 74(6):555-65. PMID: 20946257

 

Hattori T, Konno S, Hizawa N, Isada A, Takahashi A, Shimizu K, Shimizu K, Gao P, Beaty TH, Barnes KC, Huang SK, Nishimura M. Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations. Immunogenetics. 2009 Dec;61(11-12):731-8. Epub 2009 Nov 10. PMID: 19902202


Colton CA, Mott RT, Sharpe H, Xu Q, Van Nostrand WE, Vitek MP. Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. J Neuroinflammation. 2006 Sep 27;3:27. PMID: 17005052
 

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