Response to Tuberculin Test

Certainty Style Key

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True Likely Speculative

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Human Uniqueness Relative to "Great Apes":

Likely

MOCA Domain:

Immunology

MOCA Topic Authors:

Ajit Varki

Tuberculin (an extract of mycobacterial cell walls) is used as a skin antigen challenge for testing tuberculosis exposure and sub-clinical infections in humans and captive great apes. Chimpanzees are said to require up to 10 times the dose of this antigen for a comparable positive reaction. This implies a reduction in the "delayed-type hypersensitivity" reaction, which involves several kinds of white blood cells, particularly T cells.

Referenced By:

Psoriasis

Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

the common ancestor of humans and chimpanzees was 6000K years ago
the emergence of the genus Homo was 2000K years ago
the common ancestor of modern humans was 100K years ago
the common ancestor of humans and old world monkeys was 25000K years ago

Possible Appearance:

6000K Years

Probable Appearance:

2000K Years

Definite Appearance:

100K Years

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