Admixture facilitates genetic adaptations to high altitude in Tibet.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Jeong, Choongwon; Alkorta-Aranburu, Gorka; Basnyat, Buddha; Neupane, Maniraj; Witonsky, David B; Pritchard, Jonathan K; Beall, Cynthia M; Di Rienzo, Anna
Year of Publication: 2014
Journal: Nat Commun
Volume: 5
Pagination: 3281
Date Published: 2014
Publication Language: eng
ISSN: 2041-1723
Keywords: Adaptation, Biological, Adult, Altitude, Asian Continental Ancestry Group, Basic Helix-Loop-Helix Transcription Factors, Female, Gene Flow, Humans, Hypoxia-Inducible Factor-Proline Dioxygenases, Male, Middle Aged, Tibet, Young Adult

Admixture is recognized as a widespread feature of human populations, renewing interest in the possibility that genetic exchange can facilitate adaptations to new environments. Studies of Tibetans revealed candidates for high-altitude adaptations in the EGLN1 and EPAS1 genes, associated with lower haemoglobin concentration. However, the history of these variants or that of Tibetans remains poorly understood. Here we analyse genotype data for the Nepalese Sherpa, and find that Tibetans are a mixture of ancestral populations related to the Sherpa and Han Chinese. EGLN1 and EPAS1 genes show a striking enrichment of high-altitude ancestry in the Tibetan genome, indicating that migrants from low altitude acquired adaptive alleles from the highlanders. Accordingly, the Sherpa and Tibetans share adaptive haemoglobin traits. This admixture-mediated adaptation shares important features with adaptive introgression. Therefore, we identify a novel mechanism, beyond selection on new mutations or on standing variation, through which populations can adapt to local environments.

DOI: 10.1038/ncomms4281
Alternate Journal: Nat Commun