AHI1, a pivotal neurodevelopmental gene, and C6orf217 are associated with susceptibility to schizophrenia.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Amann-Zalcenstein, Daniela; Avidan, Nili; Kanyas, Kyra; Ebstein, Richard P; Kohn, Yoav; Hamdan, Adnan; Ben-Asher, Edna; Karni, Osnat; Mujaheed, Muhammed; Segman, Ronnen H; Maier, Wolfgang; Macciardi, Fabio; Beckmann, Jacques S; Lancet, Doron; Lerer, Bernard
Year of Publication: 2006
Journal: Eur J Hum Genet
Volume: 14
Issue: 10
Pagination: 1111-9
Date Published: 2006 Oct
Publication Language: eng
ISSN: 1018-4813
Keywords: Adaptor Proteins, Signal Transducing, Arabs, Chromosomes, Human, Pair 6, Genetic Predisposition to Disease, Haplotypes, Humans, Israel, Linkage Disequilibrium, Open Reading Frames, Polymorphism, Single Nucleotide, Schizophrenia

Schizophrenia, a severe neuropsychiatric disorder, is believed to involve multiple genetic factors. A significant body of evidence supports a pivotal role for abnormalities of brain development in the disorder. Linkage signals for schizophrenia map to human chromosome 6q. To obtain a finer localization, we genotyped 180 single nucleotide polymorphisms (SNPs) in a young, inbred Arab-Israeli family sample with a limited number of founders. The SNPs were mostly within a approximately 7 Mb region around the strong linkage peak at 136.2 Mb that we had previously mapped. The most significant genetic association with schizophrenia for single SNPs and haplotypes was within a 500 kb genomic region of high linkage disequilibrium (LD) at 135.85 Mb. In a different, outbred, nuclear family sample that was not appropriate for linkage analysis, under-transmitted haplotypes incorporating the same SNPs (but not the individual SNPs) were significantly associated with schizophrenia. The implicated genomic region harbors the Abelson Helper Integration Site 1 (AHI1) gene, which showed the strongest association signal, and an adjacent, primate-specific gene, C6orf217. Mutations in human AHI1 underlie the autosomal recessive Joubert Syndrome with brain malformation and mental retardation. Previous comparative genomic analysis has suggested accelerated evolution of AHI1 in the human lineage. C6orf217 has multiple splice isoforms and is expressed in brain but does not seem to encode a functional protein. The two genes appear in opposite orientations and their regulatory upstream regions overlap, which might affect their expression. Both, AHI1 and C6orf217 appear to be highly relevant candidate genes for schizophrenia.

DOI: 10.1038/sj.ejhg.5201675
Alternate Journal: Eur. J. Hum. Genet.