Commentary: is Alzheimer's disease uniquely human

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Finch, CE; Austad, SN
Year of Publication: 2015
Journal: Neurobiol Aging
Volume: 36
Number: 2
Pagination: 553-5
Date Published: Feb
Publication Language: eng
ISBN Number: 0197-4580
Accession Number: 25533426

That Alzheimer's disease (AD) might be a human-specific disease was hypothesized by Rapoport in 1989. Apes and humans share an identical amyloid beta (Aβ) peptide amino acid sequence and accumulate considerable Aβ deposits after age 40 years, an age when amyloid plaques are uncommon in humans. Despite their early Aβ buildup, ape brains have not shown evidence dystrophic neurites near plaques. Aging great ape brains also have few neurofibrillary tangles, with one exception of 1 obese chimpanzee euthanized after a stroke who displayed abundant neurofibrillary tangles, but without the typical AD distribution. We discuss the need for more exacting evaluation of neuron density with age, and note husbandry issues that may allow great apes to live to greater ages. We remain reserved about expectations for fully developed AD-like pathology in the great apes of advanced ages and cautiously support Rapoport's hypothesis.

DOI: 10.1016/j.neurobiolaging.2014.10.025