Comparative analyses reveal a complex history of molecular evolution for human MYH16.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Perry, George H; Verrelli, Brian C; Stone, Anne C
Year of Publication: 2005
Journal: Mol Biol Evol
Volume: 22
Issue: 3
Pagination: 379-82
Date Published: 03/2005
Publication Language: eng
ISSN: 0737-4038
Keywords: Animals, Evolution, Molecular, Exons, Humans, Introns, Myosin Heavy Chains, Pan troglodytes, Pseudogenes, Sequence Deletion

We describe the pattern of molecular evolution at a sarcomeric myosin gene, MYH16, using more than 30,000 bp of exon and intron sequence data from the chimpanzee and human genome sequencing projects to evaluate the timing and consequences of a human lineage-specific frameshift deletion. We estimate the age of the deletion at approximately 5.3 MYA. This estimate is consistent with the time of human and chimpanzee divergence and is significantly older than the first appearance of the genus Homo in the fossil record. We also find conflicting estimates of nonsynonymous fixation rates (d(N)) across different regions of this gene, revealing a complex pattern inconsistent with a simple model of pseudogene evolution for human MYH16.

DOI: 10.1093/molbev/msi004
Alternate Journal: Mol. Biol. Evol.