Comparative genetics of MHC polymorphisms in different primate species: duplications and deletions.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Bontrop, Ronald E
Year of Publication: 2006
Journal: Hum Immunol
Volume: 67
Issue: 6
Pagination: 388-97
Date Published: 2006 Jun
Publication Language: eng
ISSN: 0198-8859
Keywords: Animals, Evolution, Molecular, Gene Deletion, Gene Duplication, Genes, MHC Class I, Genes, MHC Class II, HLA-A Antigens, HLA-B Antigens, HLA-C Antigens, Humans, Major Histocompatibility Complex, Polymorphism, Genetic, Primates, Species Specificity

Gene products of the major histocompatibility complex (MHC) play a crucial role in the activation of adaptive (antigen-dependent) immune responses. In this paper similarities and dissimilarities among the MHCs of different primate species and their functional implications are reviewed. The human HLA system represents the most thoroughly investigated MHC of any contemporary living primate species, and so it will serve as a reference.

DOI: 10.1016/j.humimm.2006.03.007
Alternate Journal: Hum. Immunol.
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