Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst.

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Denton, D; Shade, R; Zamarippa, F; Egan, G; Blair-West, J; McKinley, M; Fox, P
Year of Publication: 1999
Journal: Proc Natl Acad Sci U S A
Volume: 96
Number: 5
Pagination: 2532-7
Date Published: Mar 2
Publication Language: eng
Accession Number: 10051677
Keywords: Adult, Brain Mapping, Brain/blood supply/*physiology/radionuclide imaging, Cerebrovascular Circulation/*physiology, Humans, Magnetic Resonance Imaging, Male, Oxygen Radioisotopes/diagnostic use/pharmacokinetics, Regional Blood Flow, Satiation/*physiology

Positron emission tomography studies were conducted during genesis of moderate thirst by rapid i.v. infusion of hypertonic saline (0.51 M) and after satiation of thirst by drinking water. The correlation of regional cerebral blood flow with the change in the plasma Na concentration showed a significant group of cerebral activations in the anterior cingulate region and also a site in the middle temporal gyrus and in the periaqueductal gray. Strongest deactivations occurred in the parahippocampal and frontal gyri. The data are consistent with an important role of the anterior cingulate in the genesis of thirst.


Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2532-7.

Author Address:

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.