Evidence for convergent evolution of A and B blood group antigens in primates.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: O'hUigin, C; Sato, A; Klein, J
Year of Publication: 1997
Journal: Hum Genet
Volume: 101
Issue: 2
Pagination: 141-8
Date Published: 1997 Dec
Publication Language: eng
ISSN: 0340-6717
Keywords: ABO Blood-Group System, Animals, Base Sequence, Evolution, Molecular, Gorilla gorilla, Hominidae, Humans, Molecular Sequence Data, Pan troglodytes, Phylogeny, Polymerase Chain Reaction, Primates, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid

To determine whether convergent or trans-specific evolution is responsible for the persistence of the ABO polymorphism in apes, we have sequenced segments of introns 5 and 6 of the ABO gene. Four substitutions and one insertion or deletion group human A, B, and O alleles together, separate from their chimpanzee A and gorilla B counterparts. No shared substitutions support a trans-species mode of evolution for any of the alleles examined. We conclude that the A and B antigens of the chimpanzee and gorilla, respectively, have arisen by convergent evolution. Phylogenetic analysis suggests that the human A and B alleles are ancient, having diverged at least 3 million years ago. These alleles must have therefore been trans-specifically inherited within the genus Homo.

Alternate Journal: Hum. Genet.