Evolution of genetic and genomic features unique to the human lineage

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: O'Bleness, M; Searles, VB; Varki, A; Gagneux, P; Sikela, JM
Year of Publication: 2012
Journal: Nat Rev Genet
Volume: 13
Edition: 2012/11/17
Number: 12
Pagination: 853-66
Date Published: Dec
Type of Article: Comparative StudyResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReview
Publication Language: eng
ISBN Number: 1471-0064 (Electronic)14
Keywords: *Evolution, *Genome, Animals, Chromosomes, Comparative Genomic Hybridization, Genetic Speciation, Genomics/trends, Hominidae/genetics, Human, Human/genetics, Humans, Karyotyping, Molecular, Phenotype, Primates/genetics, Species Specificity

Given the unprecedented tools that are now available for rapidly comparing genomes, the identification and study of genetic and genomic changes that are unique to our species have accelerated, and we are entering a golden age of human evolutionary genomics. Here we provide an overview of these efforts, highlighting important recent discoveries, examples of the different types of human-specific genomic and genetic changes identified, and salient trends, such as the localization of evolutionary adaptive changes to complex loci that are highly enriched for disease associations. Finally, we discuss the remaining challenges, such as the incomplete nature of current genome sequence assemblies and difficulties in linking human-specific genomic changes to human-specific phenotypic traits.


Nat Rev Genet. 2012 Dec;13(12):853-66. doi: 10.1038/nrg3336.

Alternate Journal: Nature reviews. Genetics
Author Address:

Department of Biochemistry and Molecular Genetics, Human Medical Genetics and Neuroscience Programs, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.