Genome Sequencing Technology and Algorithms
he 2003 completion of the Human Genome Project was just one step in the evolution of DNA sequencing. Now from a "who's who" of pioneers in the field comes the latest genome sequencing and assembly advances that are redefining the field. This trail-blazing work gives researchers unparalleled access to state-of-the-art DNA sequencing technologies, new algorithmic sequence assembly techniques, and emerging methods for both resequencing and genome analysis that together form the most solid foundation possible for tackling experimental and computational challenges in the genome sciences today.An overview of new DNA sequencing technology -- Array-based pyrosequencing technology -- The role of resequencing arrays in revolutionizing DNA sequencing -- Polony sequencing -- Genome sequencing: a complex path to personalized medicine -- Overview of genome assembly techniques -- Fragment assembly algorithms -- Assembly for double-ended short read sequencing technologies -- Genome characterization in the post-human genome project era -- The haplotyping problem: an overview of computational models and solutions -- Analysis of genomic alterations in cancer -- High-throughput assessments of epigenomics in human disease -- Comparative sequencing, assembly, and anchoring
