Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Ajit Varki
Year of Publication: 2007
Journal: Nature
Volume: 446
Issue: 7139
Pagination: 1023-9
Date Published: 04/2007
Publication Language: eng
ISSN: 1476-4687
Keywords: Animals, Evolution, Molecular, Humans, N-Acetylneuraminic Acid, Polysaccharides, Protein Binding, Proteins, Vertebrates

All cells in nature are covered by a dense and complex array of carbohydrates. Given their prominence on cell surfaces, it is not surprising that these glycans mediate and/or modulate many cellular interactions. Proteins that bind sialic acid, a sugar that is found on the surface of the cell and on secreted proteins in vertebrates, are involved in a broad range of biological processes, including intercellular adhesion, signalling and microbial attachment. Studying the roles of such proteins in vertebrates has improved our understanding of normal physiology, disease and human evolution.

DOI: 10.1038/nature05816
Alternate Journal: Nature