Going retro: ancient viral origins of cognition.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Campioni, Matthew R; Finkbeiner, Steven
Year of Publication: 2015
Journal: Neuron
Volume: 86
Issue: 2
Pagination: 346-8
Date Published: 2015 Apr 22
Publication Language: eng
ISSN: 1097-4199
Keywords: Animals, Cognition disorders, Genes, Immediate-Early, Neuronal Plasticity, Retroelements, Synapses

In this issue of Neuron, Zhang et al. (2015) provide the first crystal structure of a domain Arc. These results confirm prior computational approaches that suggested Arc, a master regulator of vertebrate synaptic plasticity, was "domesticated" from Ty3/Gypsy retrotransposons.

DOI: 10.1016/j.neuron.2015.04.008
Alternate Journal: Neuron