How the extracellular matrix shapes neural development

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Long KR; Huttner WB
Year of Publication: 2019
Journal: Open Biol.
Volume: 9
Issue: 1
Pagination: 180216
Publication Language: eng

During development, both cells and tissues must acquire the correct shape to allow their proper function. This is especially relevant in the nervous system, where the shape of individual cell processes, such as the axons and dendrites, and the shape of entire tissues, such as the folding of the neocortex, are highly specialized. While many aspects of neural development have been uncovered, there are still several open questions concerning the mechanisms governing cell and tissue shape. In this review, we discuss the role of the extracellular matrix (ECM) in these processes. In particular, we consider how the ECM regulates cell shape, proliferation, differentiation and migration, and more recent work highlighting a key role of ECM in the morphogenesis of neural tissues.




doi: 10.1098/rsob.180216

Short Title: Open Biology