The Human Frontal Lobes: Functions and Disorders
Recent years have seen exciting advances in our understanding of the human frontal lobes and their role in diverse cognitive processes, social behaviors, and psychiatric disorders. This volume brings together current research on these important regions of the brain, examining their functions in both health and disease. Significant findings on anatomy, chemistry, and physiology are first presented. Next, chapters address such neuropsychological functions as working memory, attention, inhibition, idea and word generation, and language, tracing their links to the frontal lobes and describing new and established approaches to assessment and testing. Proceeding to clinical manifestations of pathology, contributors examine the impact upon the frontal lobes of tumors, trauma, and various neurological diseases, and explore the role of frontal lobe dysfunction in psychiatric disorders including schizophrenia, obsessive-compulsive disorder, depression, and antisocial behavior.PT. 1. OVERVIEW OF THE FRONTAL LOBES -- 1. The human frontal lobes : an introduction / Bruce L. Miller -- 2. Conceptual and clinical aspects of the frontal lobes / Jeffrey L. Cummings and Bruce L. Miller -- PT. 2. ANATOMY -- 3. Frontal-subcortical circuits / Tiffany W. Chow and Jeffrey L. Cummings -- 4. The dorsolateral and cingulate cortex / Daniel I. Kaufer -- 5. The orbitofrontal cortex and the insula / Jennifer Ogar and Maria Luisa Gorno-Tempini -- 6. Structural and frontal asymmetries of the human frontal lobes / Daniel H. Geschwind and Marco Iacoboni -- 7. Gross morphology and architectonics / Daniella Andrea Carlin -- 8. Evolution of the frontal lobes / Harry J. Jerison -- PT. 3. NEUROCHEMISTRY -- 9. Serotonin and the frontal lobes / Philippe H. Robert, Michel Benoit, and Hervé Caci -- 10. Oiling the gears of the mind : roles for acetylcholine in the modulation of attention / Serena Amici and Adam L. Boxer -- 11. The mesocortical dopaminergic system / Antonello Bonci and Susan Jones -- PT. 4. FUNCTIONAL AND STRUCTURAL IMAGING APPROACHES -- 12. Structural imaging of the frontal lobes / Howard Rosen and David Dean -- 13. Unifying prefrontal cortex function : executive control, neural networks, and top-down modulation / Adam Gazzaley and Mark D'Esposito -- 14. Insight into frontal lobe function from functional neuroimaging studies of episodic memory / W. Dale Stevens and Cheryl L. Grady -- 15. The frontal lobes and autobiographical memory / Margaret C. McKinnon, Eva Svoboda, and Brian Levine -- 16. Planning and the brain / Jordan Grafman -- 17. Principles of motor control by the frontal lobes as revealed by the study of voluntary eye movements / Adam L. Boxer -- PT. 5. NEUROPSYCHOLOGICAL FUNCTIONS -- 18. Bedside frontal lobe testing / Joel H. Kramer and Lovingly Quitania -- 19. New approaches to prefrontal lobe testing / Donald T. Stuss -- 20. Language and frontal cortex / Argye E. Hillis -- 21. Self-representation and the frontal lobes / William W. Seeley and Virginia E. Sturm -- 22. Frontal dysfunction and capacity to consent to treatment or research : conceptual considerations and empirical evidence / Laura B. Dunn, Barton W. Palmer, and Jason H.T. Karlawish -- 23. Social cognition in frontal injury / Katherine P. Rankin -- PT. 6. NEUROLOGICAL DISEASES -- 24. Clinical aspects of frontotemporal dementia / Pei-Ning Wang and Bruce L. Miller -- 25. Genetics and neuropathology of frontotemporal dementia / Nigel J. Cairns, Virginia M.-Y. Lee, and John Q. Trojanowski -- 26. Imaging in frontotemporal dementia / Murray Grossman -- 27. Progressive supranuclear palsy, corticobasal degeneration, and the frontal cortex / Irene van Balken and Irene Litvan -- 28. Frontal variant of Alzheimer's disease / Julene K. Johnson, Arne Brun, and Elizabeth Head -- 29. Vascular disease of the frontal lobes / Ae Young Lee and Helena Chui -- 30. Parkinson's disease with and without dementia and Lewy body dementia / Bruno Dubois, Bernard Pillon, and Ian G. McKeith -- 31. Neurosurgical intervention for psychiatric illness : past, present, and future / Anthony P. Weiss, Scott L. Rauch, and Bruce H. Price -- 32. Infectious, inflammatory, and demyelinating disorders / Douglas W. Scharre -- 33. Traumatic brain injury / Judith Aharon-Peretz and Rachel Tomer -- 34. Adult-onset genetic disorders involving the frontal lobes / Michael D. Geschwind, Grace Yoon, and Jill Goldman -- 35. Frontal lobe development in childhood / Carole Samango-Sprouse -- PT. 7. PSYCHIATRIC DISEASES -- 36. Frontal lobe functioning in schizophrenia : evidence from neuropsychology, cognitive neuroscience, and psychophysiology / Susan A. Legendre Ropacki and William Perry -- 37. Bipolar disorder and the frontal lobes / Mary G. DeMay, Danijela Pavlic, and Bruce L. Miller -- 38. Obsessive-compulsive disorder and the frontal lobes / Denys Fontaine, Vianney Mattei, and Philippe H. Robert -- 39. Depression and the frontal lobes / Ira M. Lesser and Julia A. Chung
