Human is a unique species among primates in terms of telomere length.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Kakuo, S; Asaoka, K; Ide, T
Year of Publication: 1999
Journal: Biochem Biophys Res Commun
Volume: 263
Issue: 2
Pagination: 308-14
Date Published: 1999 Sep 24
Publication Language: eng
ISSN: 0006-291X
Keywords: Aging, Animals, Cell Aging, DNA Restriction Enzymes, Female, Hominidae, Humans, Macaca, Male, Pan troglodytes, Pongo pygmaeus, Telomerase, Telomere, Tissue Distribution

TRF (terminal restriction fragments) length in various tissues of non-human primates such as Macaca mulatta (rhesus monkey), Macaca fuscata (Japanese monkey), Macaca fascicularis (crab-eating monkey), Pan troglodytes (common chimpanzee), and Pongo pygmaeus (orangutan) was at least 23 kb without exception, which was quite different from that of human somatic tissues (smaller than 10 kb). The distribution pattern of telomerase activity among tissues was similar between human and non-human primates, while the activity level showed some differences such as that strong telomerase activity was observed in gastrointestinal and lymphocytic tissues from non-human primates. The human appears to be a unique species among primates in terms of telomere length.

DOI: 10.1006/bbrc.1999.1385
Alternate Journal: Biochem. Biophys. Res. Commun.
Related MOCA Topics: