Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Gapp, Katharina; Jawaid, Ali; Sarkies, Peter; Bohacek, Johannes; Pelczar, Pawel; Prados, Julien; Farinelli, Laurent; Miska, Eric; Mansuy, Isabelle M
Year of Publication: 2014
Journal: Nat Neurosci
Volume: 17
Issue: 5
Pagination: 667-9
Date Published: 2014 May
Publication Language: eng
ISSN: 1546-1726
Keywords: Animals, Animals, Newborn, Cell Line, Tumor, Dark Adaptation, Disease Models, Animal, Energy Intake, Female, Gene Expression Regulation, Male, Maternal deprivation, Maze Learning, Mice, Mice, Inbred C57BL, MicroRNAs, Oocytes, Reaction Time, RNA, Small Interfering, RNA, Small Untranslated, Spermatozoa, Stress, Psychological

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

DOI: 10.1038/nn.3695
Alternate Journal: Nat. Neurosci.