Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.
Publication Type: Journal Article
Authors: Gapp, Katharina; Jawaid, Ali; Sarkies, Peter; Bohacek, Johannes; Pelczar, Pawel; Prados, Julien; Farinelli, Laurent; Miska, Eric; Mansuy, Isabelle M
Year of Publication: 2014
Journal: Nat Neurosci
Date Published: 2014 May
Publication Language: eng
Keywords: Animals, Animals, Newborn, Cell Line, Tumor, Dark Adaptation, Disease Models, Animal, Energy Intake, Female, Gene Expression Regulation, Male, Maternal deprivation, Maze Learning, Mice, Mice, Inbred C57BL, MicroRNAs, Oocytes, Reaction Time, RNA, Small Interfering, RNA, Small Untranslated, Spermatozoa, Stress, Psychological
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
Alternate Journal: Nat. Neurosci.