The importance of including ethnically diverse populations in studies of quantitative trait evolution.

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: McQuillan, Michael A; Zhang, Chao; Tishkoff, Sarah A; Platt, Alexander
Year of Publication: 2020
Journal: Curr Opin Genet Dev
Volume: 62
Pagination: 30-35
Date Published: 2020 Jun
Publication Language: eng
ISSN: 1879-0380
Keywords: Biological Evolution, Ethnicity, Genetic Variation, Genetics, Population, Humans, Phenotype, Quantitative Trait Loci, Selection, Genetic
Abstract:

For many traits, human variation is less a matter of categorical differences than quantitative variation, such as height, where individuals fall along a continuum from short to tall. Most recent studies utilize large population-based samples with whole-genome sequences to study the evolution of these traits and have made significant progress implementing a broad spectrum of techniques. However, relatively few studies of quantitative trait evolution include ethnically diverse populations, which often harbor the highest levels of genetic and phenotypic diversity. Thus, our ability to draw inferences about quantitative trait adaptation has been limited. Here, we review recent studies examining human quantitative trait adaptation, and argue that including ethnically diverse populations, particularly from Africa, will be especially informative for our understanding of how humans adapt to the world around them.

DOI: 10.1016/j.gde.2020.05.037
Alternate Journal: Curr Opin Genet Dev