Interneurons of the neocortical inhibitory system.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Markram, Henry; Toledo-Rodriguez, Maria; Wang, Yun; Gupta, Anirudh; Silberberg, Gilad; Wu, Caizhi
Year of Publication: 2004
Journal: Nat Rev Neurosci
Volume: 5
Issue: 10
Pagination: 793-807
Date Published: 2004 Oct
Publication Language: eng
ISSN: 1471-003X
Keywords: Animals, Axons, Calcium-Binding Proteins, Dendrites, Electrophysiology, Humans, Interneurons, Ion Channels, Membrane Potentials, Neocortex, Nerve Net, Neural Inhibition, Neurons, Neuropeptides, Synapses, Synaptic Transmission

Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to have arisen from repeated duplication of a stereotypical microcircuit template with subtle specializations for different brain regions and species. The quest to unravel the blueprint of this template started more than a century ago and has revealed an immensely intricate design. The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.

DOI: 10.1038/nrn1519
Alternate Journal: Nat. Rev. Neurosci.