Mitochondrial DNA variation in human radiation and disease.
Publication Type: Journal Article
Authors: Wallace, Douglas C
Year of Publication: 2015
Date Published: 2015 Sep 24
Publication Language: eng
Keywords: Animals, Disease, DNA, Mitochondrial, Female, Genetic Speciation, Genetic Variation, Genetics, Medical, Human Migration, Humans, Oxidative Phosphorylation
Environmental adaptation, predisposition to common diseases, and, potentially, speciation may all be linked through the adaptive potential of mitochondrial DNA (mtDNA) alterations of bioenergetics. This Perspective synthesizes evidence that human mtDNA variants may be adaptive or deleterious depending on environmental context and proposes that the accrual of mtDNA variation could contribute to animal speciation via adaptation to marginal environments.
Alternate Journal: Cell