The origin of human chromosome 18 from a human/ape ancestor.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: McConkey, E H
Year of Publication: 1997
Journal: Cytogenet Cell Genet
Volume: 76
Issue: 3-4
Pagination: 189-91
Date Published: 1997
Publication Language: eng
ISSN: 0301-0171
Keywords: Animals, Chromosomes, Human, Pair 18, Hominidae, Humans, In Situ Hybridization, Fluorescence

Karyotype analysis by previous investigators demonstrated that human chromosome 18 differs from homologous chromosomes in the great apes by a pericentric inversion. The present study uses fluorescence in situ hybridization on human and pygmy chimpanzee chromosomes to confirm the inversion and to delimit the regions where the breakpoints must have occurred in the human/ape ancestor.

Alternate Journal: Cytogenet. Cell Genet.