Protein dynamics and the allosteric transitions of pentameric receptor channels

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Changeux, J.P.
Year of Publication: 2014
Journal: Biophys Rev
Volume: 6
Number: 3-4
Pagination: 311-321
Date Published: 11/2014
Publication Language: eng
Accession Number: 25505495
Keywords: Acetylcholine receptor, Allosteric interactions, Conformational changes, Molecular dynamics

The recent application of molecular dynamics (MD) methodology to investigate the allosteric transitions of the acetylcholine receptor and its prokaryotic and eukaryotic pentameric homologs has yielded new insights into the mechanisms of signal transduction by these receptors. Combined with available data on X-ray structures, MD techniques enable description of the dynamics of the conformational change at the atomic level, intra-molecular propagation of this signal transduction mechanism as a concerted stepwise process at physiological timescales and the control of this process by allosteric modulators, thereby offering new perspectives for drug design.


Biophys Rev 2014. 6:311-321. 10.1007/s12551-014-0149-z