Re-valuing the amygdala.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Morrison, S. E.; Salzman, C. D.
Year of Publication: 2010
Journal: Curr Opin Neurobiol
Volume: 20
Issue: 2
Pagination: 221-30
Date Published: 04/2010
Publication Language: eng
ISSN: 1873-6882
Keywords: Affect, Amygdala, Animals, Cognition, Decision making, Emotions, Fear, Humans, Judgment, Models, Animal, Motivation, Reward

Recent advances indicate that the amygdala represents valence: a general appetitive/aversive affective characteristic that bears similarity to the neuroeconomic concept of value. Neurophysiological studies show that individual amygdala neurons respond differentially to a range of stimuli with positive or negative affective significance. Meanwhile, increasingly specific lesion/inactivation studies reveal that the amygdala is necessary for processes--for example, fear extinction and reinforcer devaluation--that involve updating representations of value. Furthermore, recent neuroimaging studies suggest that the human amygdala mediates performance on many reward-based decision-making tasks. The encoding of affective significance by the amygdala might be best described as a representation of state value-a representation that is useful for coordinating physiological, behavioral, and cognitive responses in an affective/emotional context.

DOI: 10.1016/j.conb.2010.02.007
Alternate Journal: Curr. Opin. Neurobiol.
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