Recent human-specific spreading of a subtelomeric domain.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Monfouilloux, S; Avet-Loiseau, H; Amarger, V; Balazs, I; Pourcel, C; Vergnaud, G
Year of Publication: 1998
Journal: Genomics
Volume: 51
Issue: 2
Pagination: 165-76
Date Published: 1998 Jul 15
Publication Language: eng
ISSN: 0888-7543
Keywords: Animals, Base Sequence, Cell Line, Chromosome Mapping, Chromosome Segregation, CpG Islands, Evolution, Molecular, Female, Genome, Human, Humans, Lymphocytes, Male, Minisatellite Repeats, Molecular Sequence Data, Pan troglodytes, Pedigree, Pongo pygmaeus, Sequence Analysis, DNA, Telomere

The recent spreading of a subtelomeric region at nine different human chromosome ends was characterized by a combination of segregation analyses, physical mapping, junction cloning, and FISH investigations. The events occurred very recently in human genome evolution as demonstrated by sequence analysis of different alleles and the single location of the ancestral site at chromosome 17qter in chimpanzee and orangutan. The domain successfully colonized most 1p, 5q, and 6q chromosome ends and is also present at a significant frequency of 6p, 7p, 8p, 11p, 15q, and 19p ends. On 6qter, the transposed domain is immediately distal to the highly conserved, single-copy gene PDCD2.

DOI: 10.1006/geno.1998.5358
Alternate Journal: Genomics
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