Recent human-specific spreading of a subtelomeric domain.

Bibliographic Collection:

MOCA Reference, APE

Publication Type: Journal Article

Authors: Monfouilloux, S; Avet-Loiseau, H; Amarger, V; Balazs, I; Pourcel, C; Vergnaud, G

Year of Publication: 1998

Journal: Genomics

Volume: 51

Issue: 2

Pagination: 165-76

Date Published: 1998 Jul 15

Publication Language: eng

ISSN: 0888-7543

Keywords: Animals, Base Sequence, Cell Line, Chromosome Mapping, Chromosome Segregation, CpG Islands, Evolution, Molecular, Female, Genome, Human, Humans, Lymphocytes, Male, Minisatellite Repeats, Molecular Sequence Data, Pan troglodytes, Pedigree, Pongo pygmaeus, Sequence Analysis, DNA, Telomere

Abstract:

The recent spreading of a subtelomeric region at nine different human chromosome ends was characterized by a combination of segregation analyses, physical mapping, junction cloning, and FISH investigations. The events occurred very recently in human genome evolution as demonstrated by sequence analysis of different alleles and the single location of the ancestral site at chromosome 17qter in chimpanzee and orangutan. The domain successfully colonized most 1p, 5q, and 6q chromosome ends and is also present at a significant frequency of 6p, 7p, 8p, 11p, 15q, and 19p ends. On 6qter, the transposed domain is immediately distal to the highly conserved, single-copy gene PDCD2.

DOI: 10.1006/geno.1998.5358

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/9722938?dopt=Abstract

Alternate Journal: Genomics

Export: