Retrotransposons revisited: the restraint and rehabilitation of parasites.

Bibliographic Collection:

MOCA Reference, APE

Publication Type: Journal Article

Authors: Goodier, John L; Kazazian, Haig H

Year of Publication: 2008

Journal: Cell

Volume: 135

Issue: 1

Pagination: 23-35

Date Published: 10/2008

Publication Language: eng

ISSN: 1097-4172

Keywords: Animals, Genome, Human, Humans, Long Interspersed Nucleotide Elements, Retroelements, Short Interspersed Nucleotide Elements

Abstract:

Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements.

DOI: 10.1016/j.cell.2008.09.022

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/18854152?dopt=Abstract

Alternate Journal: Cell

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